Rather than binding to the receptors, CBD influences and helps prevent the receptors’ overactivation (19). Research has shown that CBD is an antagonist to CB1 and CB2 receptors. These receptors are responsible for helping regulate the body’s immune system and inflammatory response (18). Meanwhile, CB2 receptors are mainly found in immune cells and the peripheral nervous system (17). Studies also noted that CB1 receptors play a role in chronic pain and neurodegenerative disorders, like multiple sclerosis and Huntington’s disease (16). Both CB1 and CB2 receptors are primarily found in the nervous system.ĬB1 receptors are largely abundant in the central nervous system and involved in regulating pain. Studies noted two main types of cannabinoid receptors in humans, CB1 and CB2 (15). However, endocannabinoids are naturally produced by the human body.Įndocannabinoids interact with the cannabinoid receptors to help keep the body functioning smoothly.Ĭannabinoid receptors are found throughout the body. The ECS is composed of endocannabinoids, cannabinoid receptors, and enzymes.Įndocannabinoids are similar to plant-based cannabinoids or phytocannabinoids, like CBD and THC. Studies suggest ed that the ECS regulates different body functions, such as the sleep cycle, pain management, and appetite (14).
The therapeutic benefits of CBD stem from the compound’s interaction with the body’s ECS. įindings suggest ed that clinical endocannabinoid deficiency or a decrease in endocannabinoid function may lead to higher sensitivity to pain, as well as disturbances in mood, sleep, and digestion functions (13). Scientists have hypothesized that the cause of fibromyalgia may be tied to the endocannabinoid system (ECS) (12). How CBD Oil Works to Alleviate Symptoms of Fibromyalgia Meanwhile, 66.7% of adults with sleep problems experienced improved sleep quality (11). The study reported that 79.2% of adults displayed lower anxiety scores within one month of taking CBD. The findings indicated that almost all patients involved in the clinical trials tolerated CBD well, although the authors called for further research. ĬBD also showed promising results for individuals with sleep disorders and high anxiety, according to a study published in The Permanente Journal (10). The liver metabolizes and breaks down the CBD and other cannabinoids, which leads to less CBD entering the bloodstream and producing therapeutic effects (9). ĬBD undergoes the first-pass metabolism when it passes through the digestive tract. The study note d that bypassing the digestive system allows transdermal or topical CBD to have greater bioavailability or absorption rate (8).
LAZARUS CBD FIBROMYALGIA TRIAL
The trial participants were a mix of patients with different conditions causing intractable chronic pain, such as multiple sclerosis and spinal cord injury.Īdditionally, findings suggested that CBD creams and gels’ direct application to painful areas may help provide more effective relief for inflamed or swollen joints due to arthritis (7). Ĭannabidiol (CBD), the non-psychoactive component obtained from the cannabis plant, is one of the treatments people are looking into today.Įxisting studies suggest that CBD may be used to provide effective therapeutic relief for fibromyalgia symptoms, particularly for chronic pain, depression, anxiety, and sleep disturbances.Ī review of pain-related CBD studies reported that CBD treatments significantly reduced pain for the clinical trials’ patients (6). With an estimated 2% to 4% of the worldwide population being people who have fibromyalgia, many are becoming interested in trying alternative treatments to provide relief for its symptoms (5). Why People Are Taking CBD for Fibromyalgia See the Best CBD Oil for Fibromyalgia in 2022
It is recommended to seek medical advice before using any CBD product for optimal CBD dosage and ensure overall well-being.
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